General Information

  • ID:  hor004501
  • Uniprot ID:  A0A8C7D2L9
  • Protein name:  Somatostatin-25
  • Gene name:  LOC109906819
  • Organism:  Oncorhynchus kisutch (Coho salmon) (Salmo kisutch)
  • Family:  Somatostatin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SVDNLPPRERKAGCKNFYWKGFTSC
  • Length:  25(87-111)
  • Propeptide:  MKFSQIHCALALLGLALAICSQGAASQPDLDLRSRRLLQRARAASIATQEWSKRVMEDILSELSLPEVEAQKSEGSTAEAKELLERSVDNLPPRERKAGCKNFYWKGFTSC
  • Signal peptide:  MKFSQIHCALALLGLALAICSQGAAS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Caused a decline in circulating levels of plasma insulin, depletion of liver glycogen, and activation of lipolytic pathways.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  14-25
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004501_AF2.pdbhor004501_ESM.pdb

Physical Information

Mass: 333256 Formula: C129H195N37O36S2
Absent amino acids: HIMQ Common amino acids: K
pI: 9.46 Basic residues: 5
Polar residues: 10 Hydrophobic residues: 6
Hydrophobicity: -91.2 Boman Index: -6131
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 31.2
Instability Index: 2850.4 Extinction Coefficient cystines: 7115
Absorbance 280nm: 296.46

Literature

  • PubMed ID:  2877919
  • Title:  Characterization of Coho Salmon (Oncorhynchus Kisutch) Islet Somatostatins